by Saurabh Pandey, Ph.D. Student, National Institute of Plant genome Research, New Delhi-110067
Patisiron (Onpattro), a RNA-drug based on gene silencing was cleared by the U.S. Food and Drug Administration (FDA) regulations recently. This approval will pave the way for
new generation drugs by targeting disease causing genes. The mechanism of RNA interference which involves silencing of target gene by short stretch of complementary RNA molecule has been fascinating the scientific fraternity ever since its discovery. Two scientists viz., Andrew Z. Fire and Craig C. Mello shared the Noble Prize in Physiology or Medicine (2006) for their path breaking finding about RNAi which is the control mechanism that determines the flow of genetic information.
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