Category: high
Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
Human parechovirus kind 3 (HPeV3) is an etiologic agent of respiratory illnesses, meningitis, and sepsis-like sickness in each infants and adults. Monoclonal antibodies (mAbs) is usually a promising diagnostic software for antigenic illnesses corresponding to virus an infection, as they provide a excessive specificity towards a particular viral antigen. Nevertheless, so far, there isn’t any…
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Monoclonal and Bispecific Anti-BCMA Antibodies in A number of Myeloma
B-cell maturation antigen (BCMA), a member of the tumor necrosis situation receptor superfamily, is universally expressed by common and neoplastic plasma cells and performs a important operate inside the proliferation, survival and tumor improvement in various myeloma(MM). B-cell activating situation (BAFF) and a proliferation-inducing ligand (APRIL) have been acknowledged as proliferation ligands for BCMA…
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Affiliation between Neu5Gc carbohydrate and serum antibodies in opposition to it supplies the molecular hyperlink to most cancers: French NutriNet-Santé research
Background: Excessive consumption of pink and processed meat is usually related to elevated most cancers danger, notably colorectal most cancers. Antibodies in opposition to the pink meat-derived carbohydrate N-glycolylneuraminic acid (Neu5Gc) exacerbate most cancers in “human-like” mice. Human anti-Neu5Gc IgG and pink meat are each independently proposed to extend most cancers danger, but how weight-reduction…
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Advancing HIV Broadly Neutralizing Antibodies: From Discovery to the Clinic
Despite substantial progress in confronting the global HIV-1 epidemic since its inception in the 1980s, better approaches for both treatment and prevention will be necessary to end the epidemic and remain a top public health priority. Antiretroviral therapy (ART) has been effective in extending lives, but at a cost of lifelong adherence to treatment. Broadly…
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Alternative non-antibody scaffolds for molecular recognition.
Initially proposed one decade in the past, the concept of engineering proteins exterior the immunoglobulin household for novel binding capabilities has developed as a strong expertise. A number of courses of protein scaffolds proved to yield reagents with specificities and affinities in a spread that was beforehand thought of distinctive to antibodies. Such engineered protein…
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New microbial fuels: a biotech perspective.
Bioethanol and plant oil-derived biodiesel are usually thought of first technology biofuels. Recognizing their obvious disadvantages, scientists and engineers are growing extra sustainable and economically possible second technology biofuels. The brand new microbial fuels summarized right here have nice potential to grow to be viable replacements or a minimum of dietary supplements of petroleum-derived liquid…
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Novel trends in high-throughput screening.
Excessive-throughput screening (HTS) is a well-established course of for lead discovery in Pharma and Biotech firms and is now additionally getting used for fundamental and utilized analysis in academia. It contains the screening of huge chemical libraries for exercise towards organic targets through the usage of automation, miniaturized assays and large-scale information evaluation. Since its first…
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Clostridium ljungdahlii represents a microbial production platform based on syngas.
Clostridium ljungdahlii is an anaerobic homoacetogen, in a position to ferment sugars, different natural compounds, or CO(2)/H(2) and synthesis fuel (CO/H(2)). The latter characteristic makes it an attention-grabbing microbe for the biotech business, as essential bulk chemical compounds and proteins will be produced on the expense of CO(2), thus combining industrial wants with sustained discount of…
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From the laboratory bench to the patient’s bedside: an update on clinical trials with mesenchymal stem cells.
Mesenchymal Stem Cells (MSCs) are non-hematopoietic multi-potent stem-like cells which are able to differentiating into each mesenchymal and non-mesenchymal lineages. In actual fact, along with bone, cartilage, fats, and myoblasts, it has been demonstrated that MSCs are able to differentiating into neurons and astrocytes in vitro and in vivo. MSCs are of curiosity as a…
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DrugBank 3.0: a comprehensive resource for ‘omics’ research on drugs.
DrugBank is a richly annotated database of drug and drug goal info. It accommodates in depth information on the nomenclature, ontology, chemistry, construction, operate, motion, pharmacology, pharmacokinetics, metabolism and pharmaceutical properties of each small molecule and huge molecule (biotech) medicine. It additionally accommodates complete info on the goal ailments, proteins, genes and organisms on which…
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